Therapeutic applications of PARP inhibitors in ovarian cancer

PARP Inhibitors in Ovarian Cancer

Molecular Mechanisms of PARP Inhibitors in BRCA-related Ovarian Cancer

Abbreviations: PARP: Poly(Adp-Ribose) Polymerase; SSBS: Single Strand Breaks; DSBS: Double Strand Breaks; BER: Base Excision Repair; NER: Nucleic Acid Excision Repair; MMR: Mismatch Repair; HR: Homologous Recombination; NHEJ: Non-Homologous End Joining; DNA-PKCS: DNA-Dependent Protein Kinase; ORR: Objective Response Rate; PFS: Progression-Free Survival; PLD: Pegylated Liposomal Doxorubicin; OS:...

New treatment option for ovarian cancer: PARP inhibitors

Poly(ADP-ribose) polymerase (PARP), which was first described over 50 years ago by Mandel, are a family of protein enzymes involved in DNA damage response and works by recognizing the single-strand DNA break (ssDNA) and then effecting DNA repair. A double-strand DNA (dsDNA) break can be repaired by one of two different pathways: homologous recombination (HR) or non-homologous end joining (NHEJ)...

PARP inhibitors in breast cancer.

The therapeutic implications of DNA damage in cancer therapy have long been appreciated and form the basis of many successful cytotoxic chemotherapy and radiotherapy treatment strategies. A novel class of DNA repair defect targeted therapeutics that inhibit poly (ADP-Ribose) polymerase (PARP) are being rapidly developed in breast cancer based on exciting preliminary clinical activity as single ...

PARP Inhibitors for Cancer Therapy

Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to selective killing of cancer cells with BRCA1/2 mutations. Rucaparib is approved for recurrent ovarian cancers with germline or somatic mutations in BRCA1/2.